The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation
نویسندگان
چکیده
منابع مشابه
The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.
Ectopic repression of retinoic acid (RA) receptor target genes by PML/RARA and PLZF/RARA fusion proteins through aberrant recruitment of nuclear corepressor complexes drives cellular transformation and acute promyelocytic leukemia (APL) development. In the case of PML/RARA, this repression can be reversed through treatment with all-trans RA (ATRA), leading to leukemic remission. However, PLZF/R...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2009
ISSN: 0890-9369
DOI: 10.1101/gad.512009